Key Publications
Cabreiro et al., 2013 Cell
|
Scott et al., 2017 Cell
|
Pryor et al., 2019 Cell
|
Google Scholar Citations
Publications
2021
Martinez-Miguel, V.E., Lujan, C., Espie-Caullet, T., Martinez-Martinez, D., Moore, S., Backes, C., Gonzalez, S., Galimov, E.R., Brown, A.E.X., Halic, M., Tomita, K., Rallis, C., von der Haar, T., Cabreiro, F., and Bjedov, I.
Increased fidelity of protein synthesis extends lifespan.
Cell Metabolism
Klunemann, M., Andrejev, S., Blasche, S., Mateus, A., Phapale, P., Devendran, S., Vappiani, J., Simon, B., Scott, T.A., Kafkia, E., Konstantinidis, D., Zirngibl, K., Mastrorilli, E., Banzhaf, M., Mackmull, M.T., Hovelmann, F., Nesme, L., Brochado, A.R., Maier, L., Bock, T., Periwal, V., Kumar, M., Kim, Y., Tramontano, M., Schultz, C., Beck, M., Hennig, J., Zimmermann, M., Sevin, D.C., Cabreiro, F., Savitski, M.M., Bork, P., Typas, A., and Patil, K.R.
Bioaccumulation of therapeutic drugs by human gut bacteria.
Nature 597, 533-538
C Backes, D Martinez-Martinez, F Cabreiro.
C. elegans: A biosensor for host–microbe interactions.
Lab Animal 50 (5), 127-135
Y Liu, D Martinez-Martinez, CL Essmann, MR Cruz, F Cabreiro, DA Garsin
Transcriptome analysis of Caenorhabditis elegans lacking heme peroxidase SKPO-1 reveals an altered response to Enterococcus faecalis.
G3 11 (2), jkaa055
2020
GV Mkrtchyan, K Abdelmohsen et al.,
ARDD 2020: from aging mechanisms to interventions.
Aging (Albany NY) 12 (24), 24484
Ivana Bjedov, Helena M Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C Regan, Janne M Toivonen, Michael P Murphy, Janet Thornton, Kerri J Kinghorn, Thomas P Neufeld, Filipe Cabreiro, Linda Partridge
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila.
Plos Genetics (2020) 16 (11), e1009083
Essmann, C.L., Martinez-Martinez, D., Pryor, R., Leung, K.Y., Krishnan, K.B., Lui, P.P., Greene, N.D.E., Brown, A.E.X., Pawar, V.M., Srinivasan, M.A. and Cabreiro, F.
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.
Nature Communications (2020) 11, 1043.
Pryor, R, Martinez-Martinez, D, Quintaneiro, L and Cabreiro, F.
The Role of the Microbiome in Drug Response.
Annual Review of Pharmacology and Toxicology (2020) Aug 6. doi: 10.1146/annurev-pharmtox-010919-023612.
2019
Bana, B and Cabreiro, F.
The Microbiome and Aging.
Annual Review of Genetics (2019). Annu Rev Genet 53, 239-261.
Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C and Cabreiro F.
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
Cell Aug 23. pii: S0092-8674(19)30891-8. doi: 10.1016/j.cell.2019.08.003.
Rutter, J.W., Ozdemir, T., Galimov, E.R., Quintaneiro, L.M., Rosa, L., Thomas, G.M., Cabreiro, F., and Barnes, C.P.
Detecting Changes in the Caenorhabditis elegans Intestinal Environment Using an Engineered Bacterial Biosensor.
ACS Synth Biol (2019) 8, 2620-2628.
Benedetto, A., Bambade, T., Au, C., Tullet, J., Monkhouse, J., Dang, H., Cetnar, K., Chan, B., Cabreiro, F., and D. Gems.
‘New label-free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging.
Aging Cell (2019) Oct;18(5):e12998. doi: 10.1111/acel.12998.
2018
Norvaisas, P. and Cabreiro, F.
Pharmacology in the age of the holobiont.
Current Opinion in Systems Biology, (2018) 1-9.
2017
Scott, T.A., Quintaneiro L.M., Cabreiro, F. (2017)
Microbiome genetics underpins chemotherapy.
Oncotarget (2017) 55, 93393-93304.
Hastings, J., Mains, A., (…) Cabreiro, F., (...) Kaleta, C. Witting, M., and Casanueva, O.
WormJam: A consensus C. elegans Metabolic Reconstruction and Metabolomics Community and Workshop Series.
Worm 6(2):e1373939-e1373939 06 Sep 2017
Scott,T.A., Quintaneiro, L.M., Norvaisas, P., Lui, P.P., Wilson, M.P., Leung, K.Y., Herrera-Dominguez, L., Sudiwala, S., Pessia,A., Clayton,P.T., Bryson,K., Velagapudi,V., Mills, P.B., Typas,A., Greene, N.D. Cabreiro, F.
Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans.
Cell. 169, 442–456.
2016
de la Guardia, Y., Gilliat, A.F., Hellberg, J., Rennert, P., Cabreiro, F., Gems, D.,
Run-on of germline apoptosis promotes gonad senescence in C. elegans.
Oncotarget (2016) 7(26): 39082 -39096
2015
Cabreiro, F.
Metformin Joins Forces with Microbes.
Cell Host and Microbe 1, 1-3.
Pryor, R and Cabreiro, F.
Repurposing metformin: an old drug with new tricks in its binding pockets.
Biochemical Journal (2015) 471, 307-322.
2013
Cabreiro, F., and Gems, D.
Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans.
EMBO molecular medicine (2013) 5, 1300-1310.
Leung, K.Y., De Castro, S.C., Cabreiro, F., Gustavsson, P., Copp, A.J., and Greene, N.D.
Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain.
Molecular and cellular biochemistry (2013) 378, 229-236.
Cabreiro, F., Au, C., Leung, K.Y., Vergara-Irigaray, N., Cocheme, H.M., Noori, T., Weinkove, D., Schuster, E., Greene, N.D., and Gems, D.
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Cell (2013) 153, 228-239.
Coburn, C., Allman, E., Mahanti, P., Benedetto, A., Cabreiro, F., Pincus, Z., Matthijssens, F., Araiz, C., Mandel, A., Vlachos, M., et al. (2013).
Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans.
PLoS biology 11, e1001613.
Before 2012
Valentini, S., Cabreiro, F., Ackerman, D., Alam, M.M., Kunze, M.B., Kay, C.W., and Gems, D.
Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.
Mechanisms of ageing and development (2012) 133, 282-290.
Cabreiro, F., Burnett, C., Valentini, S., Goss, M., Somogyvari, M., Piper, M.D., Hoddinott, M., Sutphin, G.L., Leko, V., McElwee, J.J., et al.
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.
Nature (2011) 477, 482-485.
Cabreiro, F., Ackerman, D., Doonan, R., Araiz, C., Back, P., Papp, D., Braeckman, B.P., and Gems, D.
Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage.
Free radical biology & medicine (2011) 51, 1575-1582.
Cocheme, H.M., Quin, C., McQuaker, S.J., Cabreiro, F., Logan, A., Prime, T.A., Abakumova, I., Patel, J.V., Fearnley, I.M., James, A.M., et al.
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.
Cell Metabolism (2011) 13, 340-350
Cabreiro, F., and Gems, D. (2010).
Treating aging: progress toward dietary restriction mimetics.
F1000 biology reports 2, 76.
Larbi, A., Cabreiro, F., Zelba, H., Marthandan, S., Combet, E., Friguet, B., Petropoulos, I., Barnett, Y., and Pawelec, G. (2010).
Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation.
Free radical biology & medicine 48, 26-34.
Cabreiro, F., Picot, C.R., Perichon, M., Friguet, B., and Petropoulos, I. (2009).
Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress.
Antioxidants & redox signaling 11, 215-225.
Cabreiro, F., Picot, C.R., Perichon, M., Castel, J., Friguet, B., and Petropoulos, I. (2008).
Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage.
The Journal of Biological Chemistry 283, 16673-16681.
Cabreiro, F., Perichon, M., Jatje, J., Malavolta, M., Mocchegiani, E., Friguet, B., and Petropoulos, I. (2008).
Zinc supplementation in the elderly subjects: effect on oxidized protein degradation and repair systems in peripheral blood lymphocytes.
Experimental gerontology 43, 483-487.
Cabreiro, F., Picot, C.R., Perichon, M., Mary, J., Friguet, B., and Petropoulos, I. (2007).
Identification of proteins undergoing expression level modifications in WI-38 SV40 fibroblasts overexpressing methionine sulfoxide reductase A.
Biochimie 89, 1388-1395.
Cabreiro, F., Picot, C.R., Friguet, B., and Petropoulos, I. (2006).
Methionine sulfoxide reductases: relevance to aging and protection against oxidative stress.
Annals of the New York Academy of Sciences 1067, 37-44.
2021
Martinez-Miguel, V.E., Lujan, C., Espie-Caullet, T., Martinez-Martinez, D., Moore, S., Backes, C., Gonzalez, S., Galimov, E.R., Brown, A.E.X., Halic, M., Tomita, K., Rallis, C., von der Haar, T., Cabreiro, F., and Bjedov, I.
Increased fidelity of protein synthesis extends lifespan.
Cell Metabolism
Klunemann, M., Andrejev, S., Blasche, S., Mateus, A., Phapale, P., Devendran, S., Vappiani, J., Simon, B., Scott, T.A., Kafkia, E., Konstantinidis, D., Zirngibl, K., Mastrorilli, E., Banzhaf, M., Mackmull, M.T., Hovelmann, F., Nesme, L., Brochado, A.R., Maier, L., Bock, T., Periwal, V., Kumar, M., Kim, Y., Tramontano, M., Schultz, C., Beck, M., Hennig, J., Zimmermann, M., Sevin, D.C., Cabreiro, F., Savitski, M.M., Bork, P., Typas, A., and Patil, K.R.
Bioaccumulation of therapeutic drugs by human gut bacteria.
Nature 597, 533-538
C Backes, D Martinez-Martinez, F Cabreiro.
C. elegans: A biosensor for host–microbe interactions.
Lab Animal 50 (5), 127-135
Y Liu, D Martinez-Martinez, CL Essmann, MR Cruz, F Cabreiro, DA Garsin
Transcriptome analysis of Caenorhabditis elegans lacking heme peroxidase SKPO-1 reveals an altered response to Enterococcus faecalis.
G3 11 (2), jkaa055
2020
GV Mkrtchyan, K Abdelmohsen et al.,
ARDD 2020: from aging mechanisms to interventions.
Aging (Albany NY) 12 (24), 24484
Ivana Bjedov, Helena M Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C Regan, Janne M Toivonen, Michael P Murphy, Janet Thornton, Kerri J Kinghorn, Thomas P Neufeld, Filipe Cabreiro, Linda Partridge
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila.
Plos Genetics (2020) 16 (11), e1009083
Essmann, C.L., Martinez-Martinez, D., Pryor, R., Leung, K.Y., Krishnan, K.B., Lui, P.P., Greene, N.D.E., Brown, A.E.X., Pawar, V.M., Srinivasan, M.A. and Cabreiro, F.
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.
Nature Communications (2020) 11, 1043.
Pryor, R, Martinez-Martinez, D, Quintaneiro, L and Cabreiro, F.
The Role of the Microbiome in Drug Response.
Annual Review of Pharmacology and Toxicology (2020) Aug 6. doi: 10.1146/annurev-pharmtox-010919-023612.
2019
Bana, B and Cabreiro, F.
The Microbiome and Aging.
Annual Review of Genetics (2019). Annu Rev Genet 53, 239-261.
Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C and Cabreiro F.
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
Cell Aug 23. pii: S0092-8674(19)30891-8. doi: 10.1016/j.cell.2019.08.003.
Rutter, J.W., Ozdemir, T., Galimov, E.R., Quintaneiro, L.M., Rosa, L., Thomas, G.M., Cabreiro, F., and Barnes, C.P.
Detecting Changes in the Caenorhabditis elegans Intestinal Environment Using an Engineered Bacterial Biosensor.
ACS Synth Biol (2019) 8, 2620-2628.
Benedetto, A., Bambade, T., Au, C., Tullet, J., Monkhouse, J., Dang, H., Cetnar, K., Chan, B., Cabreiro, F., and D. Gems.
‘New label-free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging.
Aging Cell (2019) Oct;18(5):e12998. doi: 10.1111/acel.12998.
2018
Norvaisas, P. and Cabreiro, F.
Pharmacology in the age of the holobiont.
Current Opinion in Systems Biology, (2018) 1-9.
2017
Scott, T.A., Quintaneiro L.M., Cabreiro, F. (2017)
Microbiome genetics underpins chemotherapy.
Oncotarget (2017) 55, 93393-93304.
Hastings, J., Mains, A., (…) Cabreiro, F., (...) Kaleta, C. Witting, M., and Casanueva, O.
WormJam: A consensus C. elegans Metabolic Reconstruction and Metabolomics Community and Workshop Series.
Worm 6(2):e1373939-e1373939 06 Sep 2017
Scott,T.A., Quintaneiro, L.M., Norvaisas, P., Lui, P.P., Wilson, M.P., Leung, K.Y., Herrera-Dominguez, L., Sudiwala, S., Pessia,A., Clayton,P.T., Bryson,K., Velagapudi,V., Mills, P.B., Typas,A., Greene, N.D. Cabreiro, F.
Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans.
Cell. 169, 442–456.
2016
de la Guardia, Y., Gilliat, A.F., Hellberg, J., Rennert, P., Cabreiro, F., Gems, D.,
Run-on of germline apoptosis promotes gonad senescence in C. elegans.
Oncotarget (2016) 7(26): 39082 -39096
2015
Cabreiro, F.
Metformin Joins Forces with Microbes.
Cell Host and Microbe 1, 1-3.
Pryor, R and Cabreiro, F.
Repurposing metformin: an old drug with new tricks in its binding pockets.
Biochemical Journal (2015) 471, 307-322.
2013
Cabreiro, F., and Gems, D.
Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans.
EMBO molecular medicine (2013) 5, 1300-1310.
Leung, K.Y., De Castro, S.C., Cabreiro, F., Gustavsson, P., Copp, A.J., and Greene, N.D.
Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain.
Molecular and cellular biochemistry (2013) 378, 229-236.
Cabreiro, F., Au, C., Leung, K.Y., Vergara-Irigaray, N., Cocheme, H.M., Noori, T., Weinkove, D., Schuster, E., Greene, N.D., and Gems, D.
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Cell (2013) 153, 228-239.
Coburn, C., Allman, E., Mahanti, P., Benedetto, A., Cabreiro, F., Pincus, Z., Matthijssens, F., Araiz, C., Mandel, A., Vlachos, M., et al. (2013).
Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans.
PLoS biology 11, e1001613.
Before 2012
Valentini, S., Cabreiro, F., Ackerman, D., Alam, M.M., Kunze, M.B., Kay, C.W., and Gems, D.
Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.
Mechanisms of ageing and development (2012) 133, 282-290.
Cabreiro, F., Burnett, C., Valentini, S., Goss, M., Somogyvari, M., Piper, M.D., Hoddinott, M., Sutphin, G.L., Leko, V., McElwee, J.J., et al.
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.
Nature (2011) 477, 482-485.
Cabreiro, F., Ackerman, D., Doonan, R., Araiz, C., Back, P., Papp, D., Braeckman, B.P., and Gems, D.
Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage.
Free radical biology & medicine (2011) 51, 1575-1582.
Cocheme, H.M., Quin, C., McQuaker, S.J., Cabreiro, F., Logan, A., Prime, T.A., Abakumova, I., Patel, J.V., Fearnley, I.M., James, A.M., et al.
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.
Cell Metabolism (2011) 13, 340-350
Cabreiro, F., and Gems, D. (2010).
Treating aging: progress toward dietary restriction mimetics.
F1000 biology reports 2, 76.
Larbi, A., Cabreiro, F., Zelba, H., Marthandan, S., Combet, E., Friguet, B., Petropoulos, I., Barnett, Y., and Pawelec, G. (2010).
Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation.
Free radical biology & medicine 48, 26-34.
Cabreiro, F., Picot, C.R., Perichon, M., Friguet, B., and Petropoulos, I. (2009).
Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress.
Antioxidants & redox signaling 11, 215-225.
Cabreiro, F., Picot, C.R., Perichon, M., Castel, J., Friguet, B., and Petropoulos, I. (2008).
Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage.
The Journal of Biological Chemistry 283, 16673-16681.
Cabreiro, F., Perichon, M., Jatje, J., Malavolta, M., Mocchegiani, E., Friguet, B., and Petropoulos, I. (2008).
Zinc supplementation in the elderly subjects: effect on oxidized protein degradation and repair systems in peripheral blood lymphocytes.
Experimental gerontology 43, 483-487.
Cabreiro, F., Picot, C.R., Perichon, M., Mary, J., Friguet, B., and Petropoulos, I. (2007).
Identification of proteins undergoing expression level modifications in WI-38 SV40 fibroblasts overexpressing methionine sulfoxide reductase A.
Biochimie 89, 1388-1395.
Cabreiro, F., Picot, C.R., Friguet, B., and Petropoulos, I. (2006).
Methionine sulfoxide reductases: relevance to aging and protection against oxidative stress.
Annals of the New York Academy of Sciences 1067, 37-44.
